Pyrroloquinoline quinone (PQQ) prevents cognitive deficit caused by oxidative stress in rats

Kei Ohwada, Hironobu Takeda, Makiko Yamazaki, Hirosi Isogai, Masahiko Nakano, Masao Shimomura, Koji Fukui, Shiro Urano

研究成果: Article査読

75 被引用数 (Scopus)

抄録

The effects of pyrroloquinoline quinone (PQQ) and coenzyme Q10 (Co Q10), either alone or together, on the learning ability and memory function of rats were investigated. Rats fed a PQQ-supplemented diet showed better learning ability than rats fed a CoQ10-supplemented diet at the early stage of the Morris water maze test. The combination of both compounds resulted in no significant improvement in the learning ability compared with the supplementation of PQQ alone. At the late stage of the test, rats fed PQQ-, CoQ10- and PQQ + CoQ10-supplemented diets showed similar improved learning abilities. When all the groups were subjected to hyperoxia as oxidative stress for 48 h, rats fed the PQQ- and CoQ 10 supplemented diets showed better memory function than the control rats. The concurrent diet markedly improved the memory deficit of the rats caused by oxidative stress. Although the vitamin E-deficient rats fed PQQ or CoQ10 improved their learning function even when subjected to hyperoxia, their memory function was maintained by PQQ rather than by CoQ 10 after the stress. These results suggest that PQQ is potentially effective for preventing neurodegeneration caused by oxidative stress, and that its effect is independent of either antioxidant's interaction with vitamin E.

本文言語English
ページ(範囲)29-34
ページ数6
ジャーナルJournal of Clinical Biochemistry and Nutrition
42
1
DOI
出版ステータスPublished - 2008 1月
外部発表はい

ASJC Scopus subject areas

  • 医学(その他)
  • 栄養および糖尿病
  • 臨床生化学

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