Regio-controlled iodoaminocyclization reaction of an ambident nucleophile mediated by LiAl(Ot-Bu)4

Osamu Kitagawa, Masao Fujita, Hua Li, Takeo Taguchi

研究成果: Article査読

32 被引用数 (Scopus)

抄録

A new and general method of iodine-mediated cyclization reactions of unsaturated carbamates, ureas and amides which gives N-cyclized products as a single regio-isomer was achieved. The present reaction proceeds in good yield through regio-control of an ambident nucleophile by LiAl(Ot-Bu)4, and the regio-control (N-attack vs O-attack) was also found to be remarkably affected by the additive employed.

本文言語English
ページ(範囲)615-618
ページ数4
ジャーナルTetrahedron Letters
38
4
DOI
出版ステータスPublished - 1997 1月 27
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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