Regulation of melanoblast and retinal pigment epithelium development by Xenopus laevis Mitf

Mayuko Kumasaka, Shigeru Sato, Ichiro Yajima, Colin R. Goding, Hiroaki Yamamoto

研究成果: Article査読

21 被引用数 (Scopus)

抄録

Mitf is a central regulator of pigment cell development that is essential for the normal development of the melanocyte and retinal pigment epithelium (RPE) lineages. To understand better the role of Mitf, we have used the Xenopus laevis experimental system to allow a rapid examination of the role of Mitf in vivo. Here, we report the function of XlMitfα-M on melanophore development and melanization compared with that of Slug that is expressed in neural crest cells. Overexpression of XlMitfα-M led to an increase in melanophores that was partly contributed by an increase in Slug-positive cells, indicating that XlMitfα-M is a key regulator of melanocyte/melanophore development and melanization. Moreover, overexpression of a dominant-negative form of XlMitfα led to a decrease in the number of melanophores and induced abnormal melanoblast migration. We also observed an induction of ectopic RPE and extended RPE by overexpression of XlMitfα-M and possible interactions between XlMitfα and several eye-related genes essential for normal eye development.

本文言語English
ページ(範囲)523-534
ページ数12
ジャーナルDevelopmental Dynamics
234
3
DOI
出版ステータスPublished - 2005 11月
外部発表はい

ASJC Scopus subject areas

  • 発生生物学

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