A cyclodextrin-peptide hybrid (CD-peptide) bearing three units of γ-cyclodextrin, cholic acid, and a dansyl fluorophore in the side chain has been prepared. In this novel CD-peptide, the cholic acid unit acts as an internal guest and forms an intramolecular inclusion complex with γ-cyclodextrin in the CD-peptide. This intramolecular complex works as a host-guest bridge in the CD-peptide and remarkably stabilizes the α-helix structure of the CD-peptide.
|ジャーナル||Macromolecular Rapid Communications|
|出版ステータス||Published - 2001 2 28|
ASJC Scopus subject areas
- Organic Chemistry
- Polymers and Plastics
- Materials Chemistry