Remarkable stabilization of the α-helix structure by an intramolecular host-guest bridge in a cyclodextrin-peptide hybrid

Keita Hamasaki, Ryosuke Suzuki, Hisakazu Mihara, Akihiko Ueno

研究成果: Article査読

1 被引用数 (Scopus)

抄録

A cyclodextrin-peptide hybrid (CD-peptide) bearing three units of γ-cyclodextrin, cholic acid, and a dansyl fluorophore in the side chain has been prepared. In this novel CD-peptide, the cholic acid unit acts as an internal guest and forms an intramolecular inclusion complex with γ-cyclodextrin in the CD-peptide. This intramolecular complex works as a host-guest bridge in the CD-peptide and remarkably stabilizes the α-helix structure of the CD-peptide.

本文言語English
ページ(範囲)262-265
ページ数4
ジャーナルMacromolecular Rapid Communications
22
4
DOI
出版ステータスPublished - 2001 2 28
外部発表はい

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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