Rosmarinic acid inhibits lung injury induced by diesel exhaust particles

Chiaki Sanbongi, Hirohisa Takano, Naomi Osakabe, Naoko Sasa, Midori Natsume, Rie Yanagisawa, Ken Ichiro Inoue, Yoji Kato, Toshihiko Osawa, Toshikazu Yoshikawa

研究成果: Article

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Epidemiological and experimental studies have suggested that diesel exhaust particles (DEP) may be involved in recent increases in lung diseases. DEP has been shown to generate reactive oxygen species. Intratracheal instillation of DEP induces lung inflammation and edema in mice. Rosmarinic acid is a naturally occurring polyphenol with antioxidative and anti-inflammatory activities. We investigated the effects of rosmarinic acid on lung injury induced by intratracheal administration of DEP (500 μg/body) in mice. Oral supplementation with administration of rosmarinic acid (2 mg/body for 3 d) inhibited DEP-induced lung injury, which was characterized by neutrophil sequestration and interstitial edema. DEP enhanced the lung expression of keratinocyte chemoattractant (KC), interleukin-1β, monocyte chemoattractant protein-1, and macrophage inflammatory protein-1α, which was inhibited by treatment with rosmarinic acid. DEP enhanced expression of iNOS mRNA and formation of nitrotyrosine and 8-OHdG in the lung, which was also inhibited by rosmarinic acid. These results suggest that rosmarinic acid inhibits DEP-induced lung injury by the reduction of proinflammatory molecule expression. Antioxidative activities of rosmarinic acid may also contribute to its protective effects.

元の言語English
ページ(範囲)1060-1069
ページ数10
ジャーナルFree Radical Biology and Medicine
34
発行部数8
DOI
出版物ステータスPublished - 2003 4 15

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

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    Sanbongi, C., Takano, H., Osakabe, N., Sasa, N., Natsume, M., Yanagisawa, R., Inoue, K. I., Kato, Y., Osawa, T., & Yoshikawa, T. (2003). Rosmarinic acid inhibits lung injury induced by diesel exhaust particles. Free Radical Biology and Medicine, 34(8), 1060-1069. https://doi.org/10.1016/S0891-5849(03)00040-6