Rosmarinic acid inhibits lung injury induced by diesel exhaust particles

Chiaki Sanbongi, Hirohisa Takano, Naomi Osakabe, Naoko Sasa, Midori Natsume, Rie Yanagisawa, Ken Ichiro Inoue, Yoji Kato, Toshihiko Osawa, Toshikazu Yoshikawa

研究成果: Article

88 引用 (Scopus)

抄録

Epidemiological and experimental studies have suggested that diesel exhaust particles (DEP) may be involved in recent increases in lung diseases. DEP has been shown to generate reactive oxygen species. Intratracheal instillation of DEP induces lung inflammation and edema in mice. Rosmarinic acid is a naturally occurring polyphenol with antioxidative and anti-inflammatory activities. We investigated the effects of rosmarinic acid on lung injury induced by intratracheal administration of DEP (500 μg/body) in mice. Oral supplementation with administration of rosmarinic acid (2 mg/body for 3 d) inhibited DEP-induced lung injury, which was characterized by neutrophil sequestration and interstitial edema. DEP enhanced the lung expression of keratinocyte chemoattractant (KC), interleukin-1β, monocyte chemoattractant protein-1, and macrophage inflammatory protein-1α, which was inhibited by treatment with rosmarinic acid. DEP enhanced expression of iNOS mRNA and formation of nitrotyrosine and 8-OHdG in the lung, which was also inhibited by rosmarinic acid. These results suggest that rosmarinic acid inhibits DEP-induced lung injury by the reduction of proinflammatory molecule expression. Antioxidative activities of rosmarinic acid may also contribute to its protective effects.

元の言語English
ページ(範囲)1060-1069
ページ数10
ジャーナルFree Radical Biology and Medicine
34
発行部数8
DOI
出版物ステータスPublished - 2003 4 15
外部発表Yes

Fingerprint

Vehicle Emissions
Macrophage Inflammatory Proteins
Pulmonary diseases
rosmarinic acid
Chemokine CCL2
Chemotactic Factors
Polyphenols
Interleukin-1
Reactive Oxygen Species
Anti-Inflammatory Agents
Messenger RNA
Molecules

ASJC Scopus subject areas

  • Medicine(all)
  • Toxicology
  • Clinical Biochemistry

これを引用

Sanbongi, C., Takano, H., Osakabe, N., Sasa, N., Natsume, M., Yanagisawa, R., ... Yoshikawa, T. (2003). Rosmarinic acid inhibits lung injury induced by diesel exhaust particles. Free Radical Biology and Medicine, 34(8), 1060-1069. https://doi.org/10.1016/S0891-5849(03)00040-6

Rosmarinic acid inhibits lung injury induced by diesel exhaust particles. / Sanbongi, Chiaki; Takano, Hirohisa; Osakabe, Naomi; Sasa, Naoko; Natsume, Midori; Yanagisawa, Rie; Inoue, Ken Ichiro; Kato, Yoji; Osawa, Toshihiko; Yoshikawa, Toshikazu.

:: Free Radical Biology and Medicine, 巻 34, 番号 8, 15.04.2003, p. 1060-1069.

研究成果: Article

Sanbongi, C, Takano, H, Osakabe, N, Sasa, N, Natsume, M, Yanagisawa, R, Inoue, KI, Kato, Y, Osawa, T & Yoshikawa, T 2003, 'Rosmarinic acid inhibits lung injury induced by diesel exhaust particles', Free Radical Biology and Medicine, 巻. 34, 番号 8, pp. 1060-1069. https://doi.org/10.1016/S0891-5849(03)00040-6
Sanbongi, Chiaki ; Takano, Hirohisa ; Osakabe, Naomi ; Sasa, Naoko ; Natsume, Midori ; Yanagisawa, Rie ; Inoue, Ken Ichiro ; Kato, Yoji ; Osawa, Toshihiko ; Yoshikawa, Toshikazu. / Rosmarinic acid inhibits lung injury induced by diesel exhaust particles. :: Free Radical Biology and Medicine. 2003 ; 巻 34, 番号 8. pp. 1060-1069.
@article{5bf84232a61448d492f05c13081f1d60,
title = "Rosmarinic acid inhibits lung injury induced by diesel exhaust particles",
abstract = "Epidemiological and experimental studies have suggested that diesel exhaust particles (DEP) may be involved in recent increases in lung diseases. DEP has been shown to generate reactive oxygen species. Intratracheal instillation of DEP induces lung inflammation and edema in mice. Rosmarinic acid is a naturally occurring polyphenol with antioxidative and anti-inflammatory activities. We investigated the effects of rosmarinic acid on lung injury induced by intratracheal administration of DEP (500 μg/body) in mice. Oral supplementation with administration of rosmarinic acid (2 mg/body for 3 d) inhibited DEP-induced lung injury, which was characterized by neutrophil sequestration and interstitial edema. DEP enhanced the lung expression of keratinocyte chemoattractant (KC), interleukin-1β, monocyte chemoattractant protein-1, and macrophage inflammatory protein-1α, which was inhibited by treatment with rosmarinic acid. DEP enhanced expression of iNOS mRNA and formation of nitrotyrosine and 8-OHdG in the lung, which was also inhibited by rosmarinic acid. These results suggest that rosmarinic acid inhibits DEP-induced lung injury by the reduction of proinflammatory molecule expression. Antioxidative activities of rosmarinic acid may also contribute to its protective effects.",
keywords = "Diesel exhaust particles, Free radicals, Lung injury, Reactive oxygen species, Rosmarinic acid",
author = "Chiaki Sanbongi and Hirohisa Takano and Naomi Osakabe and Naoko Sasa and Midori Natsume and Rie Yanagisawa and Inoue, {Ken Ichiro} and Yoji Kato and Toshihiko Osawa and Toshikazu Yoshikawa",
year = "2003",
month = "4",
day = "15",
doi = "10.1016/S0891-5849(03)00040-6",
language = "English",
volume = "34",
pages = "1060--1069",
journal = "Free Radical Biology and Medicine",
issn = "0891-5849",
publisher = "Elsevier Inc.",
number = "8",

}

TY - JOUR

T1 - Rosmarinic acid inhibits lung injury induced by diesel exhaust particles

AU - Sanbongi, Chiaki

AU - Takano, Hirohisa

AU - Osakabe, Naomi

AU - Sasa, Naoko

AU - Natsume, Midori

AU - Yanagisawa, Rie

AU - Inoue, Ken Ichiro

AU - Kato, Yoji

AU - Osawa, Toshihiko

AU - Yoshikawa, Toshikazu

PY - 2003/4/15

Y1 - 2003/4/15

N2 - Epidemiological and experimental studies have suggested that diesel exhaust particles (DEP) may be involved in recent increases in lung diseases. DEP has been shown to generate reactive oxygen species. Intratracheal instillation of DEP induces lung inflammation and edema in mice. Rosmarinic acid is a naturally occurring polyphenol with antioxidative and anti-inflammatory activities. We investigated the effects of rosmarinic acid on lung injury induced by intratracheal administration of DEP (500 μg/body) in mice. Oral supplementation with administration of rosmarinic acid (2 mg/body for 3 d) inhibited DEP-induced lung injury, which was characterized by neutrophil sequestration and interstitial edema. DEP enhanced the lung expression of keratinocyte chemoattractant (KC), interleukin-1β, monocyte chemoattractant protein-1, and macrophage inflammatory protein-1α, which was inhibited by treatment with rosmarinic acid. DEP enhanced expression of iNOS mRNA and formation of nitrotyrosine and 8-OHdG in the lung, which was also inhibited by rosmarinic acid. These results suggest that rosmarinic acid inhibits DEP-induced lung injury by the reduction of proinflammatory molecule expression. Antioxidative activities of rosmarinic acid may also contribute to its protective effects.

AB - Epidemiological and experimental studies have suggested that diesel exhaust particles (DEP) may be involved in recent increases in lung diseases. DEP has been shown to generate reactive oxygen species. Intratracheal instillation of DEP induces lung inflammation and edema in mice. Rosmarinic acid is a naturally occurring polyphenol with antioxidative and anti-inflammatory activities. We investigated the effects of rosmarinic acid on lung injury induced by intratracheal administration of DEP (500 μg/body) in mice. Oral supplementation with administration of rosmarinic acid (2 mg/body for 3 d) inhibited DEP-induced lung injury, which was characterized by neutrophil sequestration and interstitial edema. DEP enhanced the lung expression of keratinocyte chemoattractant (KC), interleukin-1β, monocyte chemoattractant protein-1, and macrophage inflammatory protein-1α, which was inhibited by treatment with rosmarinic acid. DEP enhanced expression of iNOS mRNA and formation of nitrotyrosine and 8-OHdG in the lung, which was also inhibited by rosmarinic acid. These results suggest that rosmarinic acid inhibits DEP-induced lung injury by the reduction of proinflammatory molecule expression. Antioxidative activities of rosmarinic acid may also contribute to its protective effects.

KW - Diesel exhaust particles

KW - Free radicals

KW - Lung injury

KW - Reactive oxygen species

KW - Rosmarinic acid

UR - http://www.scopus.com/inward/record.url?scp=0037446211&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037446211&partnerID=8YFLogxK

U2 - 10.1016/S0891-5849(03)00040-6

DO - 10.1016/S0891-5849(03)00040-6

M3 - Article

C2 - 12684091

AN - SCOPUS:0037446211

VL - 34

SP - 1060

EP - 1069

JO - Free Radical Biology and Medicine

JF - Free Radical Biology and Medicine

SN - 0891-5849

IS - 8

ER -