Rotational isomerism in 2,4,6-tri-tert-butylanilides

Nobutaka Ototake, Isao Takahashi, Shiori Tsukagoshi, Tatsuki Maeda, Osamu Kitagawa

研究成果: Article

抄録

Z-Rotamers of several 2,4,6-tri-tert-butylanilides slowly isomerize at rt in CDCl3 to E-rotamers, yielding equilibrium mixtures of Z- and E-rotamers after standing for 1 week. The equilibrium ratios between the anilide rotamers in the solution depend strongly on the bulkiness of the acyl substituents as well as the formation of intramolecular hydrogen bond. Heating equilibrium mixtures in the solid state produced complete isomerization to the Z-rotamer.

本文言語English
ページ(範囲)1013-1016
ページ数4
ジャーナルTetrahedron
69
3
DOI
出版ステータスPublished - 2013 1 21

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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