Single bovine serum albumin molecule can hold plural blue-emissive gold nanoclusters: A quantitative study with two-photon excitation

Hamza Al Kindi, Ahmed Mohamed, Shinji Kajimoto, Nurbosyn Zhanpeisov, Hideyuki Horino, Yutaka Shibata, Izabela Irena Rzeznicka, Hiroshi Fukumura

研究成果: Article

8 引用 (Scopus)


Two-photon luminescence properties of gold nanoclusters (Au8NCs) encapsulated in bovine serum albumin (BSA) were investigated. A new synthesis protocol is reported to control the number of Au8 clusters in one BSA. Both one- and two-photon excitation of BSA with multiple Au8NCs gave an identical blue luminescence. The two-photon absorption (TPA) cross-section value for BSA with one Au8NCs was obtained to be 190 GM (Goeppert-Mayer) and 540 GM for BSA with three Au8NCs, at 740 nm excitation wavelength. This study shows that BSA with multiple Au8NCs may be used as a biocompatible luminescence probe for two-photon in-vivo imaging.

ジャーナルJournal of Photochemistry and Photobiology A: Chemistry
出版物ステータスPublished - 2018 4 15


ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Physics and Astronomy(all)