Slide-ring materials: New polymeric materials for dds

Masatoshi Kidowaki, Kohzo Ito, Tohiyuki Kataoka, Masatoshi Kidowaki, Kohzo Ito

研究成果: Article査読

3 被引用数 (Scopus)

抄録

We reviewed the fundamental aspects and applications of slide-ring materials as new polymeric materials for DDS. The slide-ring gel is one of the slide-ring materials using sliding features most effectively and has movable cross-linking junctions. As a result, it exhibited mechanical properties quite different from chemical gels, rather close to biomaterials. The small angle neutron scattering studies of the slide-ring gels revealed that the pulley effect relaxed the inhomogeneous structure in the slide-ring gels. In addition, we introduced the sol-gel transition of methylated polyrotaxane as a new thermoreversible DDS system. Finally, we discussed the application of the slide-ring materials to DDS with the future view.

本文言語English
ページ(範囲)592-598
ページ数7
ジャーナルDrug Delivery System
21
6
DOI
出版ステータスPublished - 2006 1 1
外部発表はい

ASJC Scopus subject areas

  • Pharmaceutical Science

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