Stereoselective synthesis of diastereomeric atropisomeric lactam with various ring sizes and their structural characterization

O. Kitagawa, M. Fujita, M. Kohriyama, H. Hasegawa, T. Taguchi

研究成果: Article査読

42 被引用数 (Scopus)

抄録

Diastereomeric atropisomeric N-ortho-tert-butylphenyl lactams with ring sizes from four to seven were prepared with high diastereoselectivity through an aminocyclization reaction. In the case of four- and five-membered ring formation, thermodynamically stable atropisomeric lactams having a trans-relationship between the ortho-tert-butyl group and the C-4 or C-5 substituent were obtained, while in the six- and seven-membered ring-forming reaction, cis-atropisomeric lactams, kinetic controlled products, were exclusively isolated. (C) 2000 Elsevier Science Ltd.

本文言語English
ページ(範囲)8539-8544
ページ数6
ジャーナルTetrahedron Letters
41
44
DOI
出版ステータスPublished - 2000 10 28
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

フィンガープリント

「Stereoselective synthesis of diastereomeric atropisomeric lactam with various ring sizes and their structural characterization」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル