抄録
Diastereomeric atropisomeric N-ortho-tert-butylphenyl lactams with ring sizes from four to seven were prepared with high diastereoselectivity through an aminocyclization reaction. In the case of four- and five-membered ring formation, thermodynamically stable atropisomeric lactams having a trans-relationship between the ortho-tert-butyl group and the C-4 or C-5 substituent were obtained, while in the six- and seven-membered ring-forming reaction, cis-atropisomeric lactams, kinetic controlled products, were exclusively isolated. (C) 2000 Elsevier Science Ltd.
本文言語 | English |
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ページ(範囲) | 8539-8544 |
ページ数 | 6 |
ジャーナル | Tetrahedron Letters |
巻 | 41 |
号 | 44 |
DOI | |
出版ステータス | Published - 2000 10月 28 |
外部発表 | はい |
ASJC Scopus subject areas
- 生化学
- 創薬
- 有機化学