Structure-activity relationship of novel menaquinone-4 analogues: Modification of the side chain affects their biological activities

Yoshitomo Suhara, Norika Hanada, Takashi Okitsu, Miho Sakai, Masato Watanabe, Kimie Nakagawa, Akimori Wada, Kazuyoshi Takeda, Kazuhiko Takahashi, Hiroaki Tokiwa, Toshio Okano

研究成果: Article

8 引用 (Scopus)

抄録

We synthesized new vitamin K analogues with demethylation or reduction of the double bonds of the side chain of menaquinone-4 (MK-4) and evaluated their SXR-mediated transcriptional activity as well as the extent of their conversion to MK-4. The results indicated that the analogue with the methyl group deleted at the 7′ site of the side chain part affected conversion activity to MK-4. In contrast, a decrease in the number of the double bonds in the side chain moiety appeared to decrease the SXR-mediated transcriptional activity.

元の言語English
ページ(範囲)1553-1558
ページ数6
ジャーナルJournal of Medicinal Chemistry
55
発行部数4
DOI
出版物ステータスPublished - 2012 2 23
外部発表Yes

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

これを引用

Structure-activity relationship of novel menaquinone-4 analogues : Modification of the side chain affects their biological activities. / Suhara, Yoshitomo; Hanada, Norika; Okitsu, Takashi; Sakai, Miho; Watanabe, Masato; Nakagawa, Kimie; Wada, Akimori; Takeda, Kazuyoshi; Takahashi, Kazuhiko; Tokiwa, Hiroaki; Okano, Toshio.

:: Journal of Medicinal Chemistry, 巻 55, 番号 4, 23.02.2012, p. 1553-1558.

研究成果: Article

Suhara, Y, Hanada, N, Okitsu, T, Sakai, M, Watanabe, M, Nakagawa, K, Wada, A, Takeda, K, Takahashi, K, Tokiwa, H & Okano, T 2012, 'Structure-activity relationship of novel menaquinone-4 analogues: Modification of the side chain affects their biological activities', Journal of Medicinal Chemistry, 巻. 55, 番号 4, pp. 1553-1558. https://doi.org/10.1021/jm2013166
Suhara, Yoshitomo ; Hanada, Norika ; Okitsu, Takashi ; Sakai, Miho ; Watanabe, Masato ; Nakagawa, Kimie ; Wada, Akimori ; Takeda, Kazuyoshi ; Takahashi, Kazuhiko ; Tokiwa, Hiroaki ; Okano, Toshio. / Structure-activity relationship of novel menaquinone-4 analogues : Modification of the side chain affects their biological activities. :: Journal of Medicinal Chemistry. 2012 ; 巻 55, 番号 4. pp. 1553-1558.
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AU - Sakai, Miho

AU - Watanabe, Masato

AU - Nakagawa, Kimie

AU - Wada, Akimori

AU - Takeda, Kazuyoshi

AU - Takahashi, Kazuhiko

AU - Tokiwa, Hiroaki

AU - Okano, Toshio

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