Structure-activity relationships in the conversion of vitamin K analogues into menaquinone-4. Substrates essential to the synthesis of menaquinone-4 in cultured human cell lines

Yoshitomo Suhara, Akimori Wada, Yoji Tachibana, Masato Watanabe, Kanae Nakamura, Kimie Nakagawa, Toshio Okano

研究成果: Article

12 引用 (Scopus)

抄録

To reveal an essential biological role of menaquinone-4, we have clarified that dietary PK was converted to menaquinone-4 (MK-4) in animal tissues using deuterated vitamin K analogues. However, the kinds of analogue converted into MK-4 have not been elucidated. In this study, we examined structure-activity relationships in the conversion of several vitamin K analogues, with a substituted side chain, into MK-4 using cultured human cell lines. The results differed with the side chain of the analogues, that is, (1) the length of the isoprene unit and (2) the number of double bonds in the side chain. These findings would be useful for clarifying the mechanism of conversion of other vitamin K homologs into MK-4 as well as related enzymes.

元の言語English
ページ(範囲)3116-3124
ページ数9
ジャーナルBioorganic and Medicinal Chemistry
18
発行部数9
DOI
出版物ステータスPublished - 2010 5 1
外部発表Yes

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Vitamin K
Cells
Substrates
Animals
Tissue
Enzymes
menatetrenone

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

これを引用

Structure-activity relationships in the conversion of vitamin K analogues into menaquinone-4. Substrates essential to the synthesis of menaquinone-4 in cultured human cell lines. / Suhara, Yoshitomo; Wada, Akimori; Tachibana, Yoji; Watanabe, Masato; Nakamura, Kanae; Nakagawa, Kimie; Okano, Toshio.

:: Bioorganic and Medicinal Chemistry, 巻 18, 番号 9, 01.05.2010, p. 3116-3124.

研究成果: Article

Suhara, Yoshitomo ; Wada, Akimori ; Tachibana, Yoji ; Watanabe, Masato ; Nakamura, Kanae ; Nakagawa, Kimie ; Okano, Toshio. / Structure-activity relationships in the conversion of vitamin K analogues into menaquinone-4. Substrates essential to the synthesis of menaquinone-4 in cultured human cell lines. :: Bioorganic and Medicinal Chemistry. 2010 ; 巻 18, 番号 9. pp. 3116-3124.
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AU - Nakamura, Kanae

AU - Nakagawa, Kimie

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