@article{cc5d0a8398604342b7464254296664e5,
title = "Structure-activity relationships in the conversion of vitamin K analogues into menaquinone-4. Substrates essential to the synthesis of menaquinone-4 in cultured human cell lines",
abstract = "To reveal an essential biological role of menaquinone-4, we have clarified that dietary PK was converted to menaquinone-4 (MK-4) in animal tissues using deuterated vitamin K analogues. However, the kinds of analogue converted into MK-4 have not been elucidated. In this study, we examined structure-activity relationships in the conversion of several vitamin K analogues, with a substituted side chain, into MK-4 using cultured human cell lines. The results differed with the side chain of the analogues, that is, (1) the length of the isoprene unit and (2) the number of double bonds in the side chain. These findings would be useful for clarifying the mechanism of conversion of other vitamin K homologs into MK-4 as well as related enzymes.",
keywords = "Analogues, Conversion, Deuterated compound, Menaquinone-4, Structure-activity relationships, Vitamin K",
author = "Yoshitomo Suhara and Akimori Wada and Yoji Tachibana and Masato Watanabe and Kanae Nakamura and Kimie Nakagawa and Toshio Okano",
note = "Funding Information: We are grateful to Dr. Makiko Sugiura, Dr. Atsuko Takeuchi, and Dr. Chisato Tode for the spectroscopic measurements at Kobe Pharmaceutical University. We also thank Eisai Co., Ltd for generously providing the intermediate of the vitamin K analogues. Y.S. acknowledges Takeda Science Foundation. This study was supported in part by a Grant-in-aid for Scientific Research (C) (Grant number 18590112 to Y.S.) from the Japan Society for the Promotion of Science. ",
year = "2010",
month = may,
day = "1",
doi = "10.1016/j.bmc.2010.03.035",
language = "English",
volume = "18",
pages = "3116--3124",
journal = "Bioorganic and Medicinal Chemistry",
issn = "0968-0896",
publisher = "Elsevier Limited",
number = "9",
}