抜粋
The rotational barriers in axially chiral quinolin-2-one and quinazolin-2-one possessing N-(ortho-tert-butyl)phenyl group were found to significantly increase in comparison with those of corresponding dihydroquinolin-2-one and dihydroquinazolin-2-one. Analysis of transition state structure during N-Ar bond rotation based on DFT calculation indicates that the increase in the rotational barrier is due to considerable distortion of the nitrogen-containing heterocyclic part.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 4332-4336 |
| ページ数 | 5 |
| ジャーナル | Tetrahedron Letters |
| 巻 | 53 |
| 発行部数 | 33 |
| DOI | |
| 出版物ステータス | Published - 2012 8 15 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
フィンガープリント Studies on rotational barriers of N-C axially chiral compounds: Increase in the rotational barrier by aromatization' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。
これを引用
Suzumura, N., Kageyama, M., Kamimura, D., Inagaki, T., Dobashi, Y., Hasegawa, H., Fukaya, H., & Kitagawa, O. (2012). Studies on rotational barriers of N-C axially chiral compounds: Increase in the rotational barrier by aromatization. Tetrahedron Letters, 53(33), 4332-4336. https://doi.org/10.1016/j.tetlet.2012.06.007