Study on structure–activity relationship of vitamin K derivatives: Conversion of the naphthoquinone part into another aromatic ring and evaluation of their neuronal differentiation-inducing activity

Hiroshi Yoshimura, Yoshihisa Hirota, Seiya Soda, Mayu Okazeri, Yuta Takagi, Atsuko Takeuchi, Chisato Tode, Maya Kamao, Naomi Osakabe, Yoshitomo Suhara

研究成果: Article

抜粋

We synthesized novel vitamin K derivatives by converting the naphthoquinone group to benzene derivatives and benzoquinone. We evaluated their neuronal differentiation activities to investigate the effect of the quinone moiety on this process. We observed that the 1,4-quinone as well as the side chain part play important roles in neuronal differentiation. We also performed QSAR analysis to predict the compounds which would have higher differentiation activity.

元の言語English
記事番号127059
ジャーナルBioorganic and Medicinal Chemistry Letters
30
発行部数8
DOI
出版物ステータスPublished - 2020 4 15

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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