Study on structure–activity relationship of vitamin K derivatives: Conversion of the naphthoquinone part into another aromatic ring and evaluation of their neuronal differentiation-inducing activity

Hiroshi Yoshimura, Yoshihisa Hirota, Seiya Soda, Mayu Okazeri, Yuta Takagi, Atsuko Takeuchi, Chisato Tode, Maya Kamao, Naomi Osakabe, Yoshitomo Suhara

研究成果: Article査読

抄録

We synthesized novel vitamin K derivatives by converting the naphthoquinone group to benzene derivatives and benzoquinone. We evaluated their neuronal differentiation activities to investigate the effect of the quinone moiety on this process. We observed that the 1,4-quinone as well as the side chain part play important roles in neuronal differentiation. We also performed QSAR analysis to predict the compounds which would have higher differentiation activity.

本文言語English
論文番号127059
ジャーナルBioorganic and Medicinal Chemistry Letters
30
8
DOI
出版ステータスPublished - 2020 4 15

ASJC Scopus subject areas

  • 生化学
  • 分子医療
  • 分子生物学
  • 薬科学
  • 創薬
  • 臨床生化学
  • 有機化学

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