Support system for histopathologic diagnosis of hepatocellular carcinoma using nuclear positions

Masanobu Takahashi, Masayuki Nakano, Muneyoshi Tomita, Kazumasa Matsunaga

研究成果: Conference contribution

6 被引用数 (Scopus)

抄録

We report support system for histopathologic diagnosis of hepatocellular carcinoma, and especially for differential diagnosis between normal and extremely well-differentiated hepatocellular carcinoma (EHCC). To extract the positions of hepatocellular nuclei, a three-step method composing candidates extraction, contours extraction and screening steps was proposed. About 83% of the nuclear positions were correctly extracted with 10% of the positions wrongly extracted. As a result, the time required to correct the wrong positions using a graphical user interface (GUI) was reduced. Nuclear density and ratio of high nuclear density area are proposed as the two features calculated using these extracted positions. Simulation results showed the effectiveness of these features for differential diagnosis between normal and EHCC. A GUI was developed that enables a user to extract the nuclear positions, to correct the positions, and to calculate the proposed features by simple button operations. The total time for processing one image and extracting the features was about 2 minutes. This system would be helpful in actual diagnosis.

本文言語English
ホスト出版物のタイトルProceedings of the IASTED International Conference on Biomedical Engineering
編集者B. Tilg
ページ219-223
ページ数5
出版ステータスPublished - 2004 12 1
イベントProceedings of the IASTED International Conference on Biomedical Engineering - Innsbruck, Austria
継続期間: 2004 2 162004 2 18

出版物シリーズ

名前Proceedings of the IASTED International Conference on Biomedical Engineering

Conference

ConferenceProceedings of the IASTED International Conference on Biomedical Engineering
CountryAustria
CityInnsbruck
Period04/2/1604/2/18

ASJC Scopus subject areas

  • Engineering(all)

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