Syntheses and biological evaluation of novel 2α-substituted 1α,25-dihydroxyvitamin D3 analogues

Yoshitomo Suhara, Ken Ichi Nihei, Hirokazu Tanigawa, Toshie Fujishima, Katsuhiro Konno, Kimie Nakagawa, Toshio Okano, Hiroaki Takayama

研究成果: Article査読

66 被引用数 (Scopus)

抄録

Novel 2α-substituted 1α,25-dihydroxyvitamin D3 analogues were efficiently synthesized and their biological activities were evaluated. 2α-Methyl-1α25-dihydroxyvitamin D3 (2), whose unique biological activities were previously reported, was modified to 2α-alkyl (ethyl and propyl) and 2α-hydroxyalkyl (hydroxymethyl, hydroxyethyl, and hydroxypropyl) analogues 3-7 by elongation of the alkyl chain and/or introduction of a terminal hydroxyl group. 2α-Hydroxypropyl-1α,25-dihydroxyvitamin D3 (7) exhibited an exceptionally potent calcium-regulating effect and a unique activity profile. (C) 2000 Elsevier Science Ltd. All rights reserved.

本文言語English
ページ(範囲)1129-1132
ページ数4
ジャーナルBioorganic and Medicinal Chemistry Letters
10
10
DOI
出版ステータスPublished - 2000 5月 15
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 分子医療
  • 分子生物学
  • 薬科学
  • 創薬
  • 臨床生化学
  • 有機化学

フィンガープリント

「Syntheses and biological evaluation of novel 2α-substituted 1α,25-dihydroxyvitamin D3 analogues」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル