Synthesis and biological activities of novel structural analogues of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand

Yoshitomo Suhara, Shinji Nakane, Shunsuke Arai, Hiroaki Takayama, Keizo Waku, Yoshio Ishima, Takayuki Sugiura

研究成果: Article査読

12 被引用数 (Scopus)

抄録

Novel analogues of 2-arachidonoylglycerol (2-AG), an endogenous cannabinoid receptor ligand, were developed. Chemical synthesis of these analogues (2-AGA105 and 2-AGA109) was accomplished starting from 2-octyn-1-ol and diethyl malonate and employing Wittig coupling of triene phosphonate with an aldehyde intermediate in a convergent and stereoselective manner. These analogues should be useful lead compounds for the development of novel 2-AG mimetics.

本文言語English
ページ(範囲)1985-1988
ページ数4
ジャーナルBioorganic and Medicinal Chemistry Letters
11
15
DOI
出版ステータスPublished - 2001 8 6
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 分子医療
  • 分子生物学
  • 薬科学
  • 創薬
  • 臨床生化学
  • 有機化学

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