Synthesis and enhanced radical scavenging activity of a conformationally constrained epigallocatechin analogue

Kohei Imai, Ikuo Nakanishi, Kazunori Anzai, Toshihiko Ozawa, Naoki Miyata, Shiro Urano, Haruhiro Okuda, Asao Nakamura, Kiyoshi Fukuhara

研究成果: Article

5 引用 (Scopus)

抜粋

The freely rotating single bond between the pyrogallol and chroman substructures in epigallocatechin (EGC) was constrained by reaction of EGC with acetone in the presence of trimethylsilyl trifluoromethanesulfonate to prepare the rigidified analog in good yield. The synthesized analog was examined for free radical scavenging activity toward the galvinoxyl radical and was found to be 27-fold more potent than EGC.

元の言語English
ページ(範囲)1417-1419
ページ数3
ジャーナルChemistry Letters
40
発行部数12
DOI
出版物ステータスPublished - 2011

ASJC Scopus subject areas

  • Chemistry(all)

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    Imai, K., Nakanishi, I., Anzai, K., Ozawa, T., Miyata, N., Urano, S., Okuda, H., Nakamura, A., & Fukuhara, K. (2011). Synthesis and enhanced radical scavenging activity of a conformationally constrained epigallocatechin analogue. Chemistry Letters, 40(12), 1417-1419. https://doi.org/10.1246/cl.2011.1417