Synthesis of 2α-propoxy-1α,25-dihydroxyvitamin D3 and comparison of its metabolism by human CYP24A1 and rat CYP24A1

Nozomi Saito, Yoshitomo Suhara, Daisuke Abe, Tatsuya Kusudo, Miho Ohta, Kaori Yasuda, Toshiyuki Sakaki, Shinobu Honzawa, Toshie Fujishima, Atsushi Kittaka

研究成果: Article査読

19 被引用数 (Scopus)

抄録

A new vitamin D3 analogue, 2α-propoxy-1α,25-dihydroxyvitamin D3 (C3O1), was synthesized starting from d-glucose as a chiral template of the A-ring with a CD-ring bromoolefin unit using the Trost coupling method. We studied the metabolism of the new analogue by human CYP24A1 and rat CYP24A1 to learn of species-based differences and found that the former has multiple metabolic pathways, but the latter has only a single pathway.

本文言語English
ページ(範囲)4296-4301
ページ数6
ジャーナルBioorganic and Medicinal Chemistry
17
13
DOI
出版ステータスPublished - 2009 7 1
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 分子医療
  • 分子生物学
  • 薬科学
  • 創薬
  • 臨床生化学
  • 有機化学

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