Synthesis of 2α-propoxy-1α,25-dihydroxyvitamin D3 and comparison of its metabolism by human CYP24A1 and rat CYP24A1

Nozomi Saito, Yoshitomo Suhara, Daisuke Abe, Tatsuya Kusudo, Miho Ohta, Kaori Yasuda, Toshiyuki Sakaki, Shinobu Honzawa, Toshie Fujishima, Atsushi Kittaka

研究成果: Article

17 引用 (Scopus)

抄録

A new vitamin D3 analogue, 2α-propoxy-1α,25-dihydroxyvitamin D3 (C3O1), was synthesized starting from d-glucose as a chiral template of the A-ring with a CD-ring bromoolefin unit using the Trost coupling method. We studied the metabolism of the new analogue by human CYP24A1 and rat CYP24A1 to learn of species-based differences and found that the former has multiple metabolic pathways, but the latter has only a single pathway.

元の言語English
ページ(範囲)4296-4301
ページ数6
ジャーナルBioorganic and Medicinal Chemistry
17
発行部数13
DOI
出版物ステータスPublished - 2009 7 1
外部発表Yes

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Calcitriol
Metabolism
Rats
Cholecalciferol
Glucose
Vitamin D3 24-Hydroxylase
Metabolic Networks and Pathways

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry
  • Medicine(all)

これを引用

Synthesis of 2α-propoxy-1α,25-dihydroxyvitamin D3 and comparison of its metabolism by human CYP24A1 and rat CYP24A1. / Saito, Nozomi; Suhara, Yoshitomo; Abe, Daisuke; Kusudo, Tatsuya; Ohta, Miho; Yasuda, Kaori; Sakaki, Toshiyuki; Honzawa, Shinobu; Fujishima, Toshie; Kittaka, Atsushi.

:: Bioorganic and Medicinal Chemistry, 巻 17, 番号 13, 01.07.2009, p. 4296-4301.

研究成果: Article

Saito, N, Suhara, Y, Abe, D, Kusudo, T, Ohta, M, Yasuda, K, Sakaki, T, Honzawa, S, Fujishima, T & Kittaka, A 2009, 'Synthesis of 2α-propoxy-1α,25-dihydroxyvitamin D3 and comparison of its metabolism by human CYP24A1 and rat CYP24A1', Bioorganic and Medicinal Chemistry, 巻. 17, 番号 13, pp. 4296-4301. https://doi.org/10.1016/j.bmc.2009.05.032
Saito, Nozomi ; Suhara, Yoshitomo ; Abe, Daisuke ; Kusudo, Tatsuya ; Ohta, Miho ; Yasuda, Kaori ; Sakaki, Toshiyuki ; Honzawa, Shinobu ; Fujishima, Toshie ; Kittaka, Atsushi. / Synthesis of 2α-propoxy-1α,25-dihydroxyvitamin D3 and comparison of its metabolism by human CYP24A1 and rat CYP24A1. :: Bioorganic and Medicinal Chemistry. 2009 ; 巻 17, 番号 13. pp. 4296-4301.
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AU - Kusudo, Tatsuya

AU - Ohta, Miho

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AU - Sakaki, Toshiyuki

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