@article{cb9f7eb308b34a82b974b654b67b0202,
title = "Synthesis of 2α-propoxy-1α,25-dihydroxyvitamin D3 and comparison of its metabolism by human CYP24A1 and rat CYP24A1",
abstract = "A new vitamin D3 analogue, 2α-propoxy-1α,25-dihydroxyvitamin D3 (C3O1), was synthesized starting from d-glucose as a chiral template of the A-ring with a CD-ring bromoolefin unit using the Trost coupling method. We studied the metabolism of the new analogue by human CYP24A1 and rat CYP24A1 to learn of species-based differences and found that the former has multiple metabolic pathways, but the latter has only a single pathway.",
keywords = "Human CYP24A1, Metabolism, Rat CYP24A1, Vitamin D analogues",
author = "Nozomi Saito and Yoshitomo Suhara and Daisuke Abe and Tatsuya Kusudo and Miho Ohta and Kaori Yasuda and Toshiyuki Sakaki and Shinobu Honzawa and Toshie Fujishima and Atsushi Kittaka",
note = "Funding Information: We are grateful to Ms. Junko Shimode and Ms. Akiko Tonoki (Teikyo University) for the spectroscopic measurements. This work has been supported in part by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology, Japan (to N.S., Y.S., T.F., and S.H.) and by Grant-in-Aid from Japan Society for the Promotion of Science (to A.K.). Copyright: Copyright 2009 Elsevier B.V., All rights reserved.",
year = "2009",
month = jul,
day = "1",
doi = "10.1016/j.bmc.2009.05.032",
language = "English",
volume = "17",
pages = "4296--4301",
journal = "Bioorganic and Medicinal Chemistry",
issn = "0968-0896",
publisher = "Elsevier Limited",
number = "13",
}