Synthesis of new vitamin K analogues as steroid and xenobiotic receptor (SXR) agonists: Insights into the biological role of the side chain part of vitamin K

Yoshitomo Suhara, Masato Watanabe, Sayaka Motoyoshi, Kimie Nakagawa, Akimori Wada, Kazuyoshi Takeda, Kazuhiko Takahashi, Hiroaki Tokiwa, Toshio Okano

研究成果: Article

18 引用 (Scopus)

抄録

Vitamin K2 has been demonstrated to induce gene expression related to bone formation through a nuclear steroid and xenobiotic receptor (SXR). We synthesized new vitamin K analogues with the same isoprene side chains symmetrically introduced at the 2 and 3 positions of 1,4-naphthoquinone and evaluated the transcriptional activity of the target gene. The transcriptional activity was related to the length of the side chain which allowed optimal interaction with ligand-binding domain of SXR.

元の言語English
ページ(範囲)4918-4922
ページ数5
ジャーナルJournal of Medicinal Chemistry
54
発行部数13
DOI
出版物ステータスPublished - 2011 7 14
外部発表Yes

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

これを引用

Synthesis of new vitamin K analogues as steroid and xenobiotic receptor (SXR) agonists : Insights into the biological role of the side chain part of vitamin K. / Suhara, Yoshitomo; Watanabe, Masato; Motoyoshi, Sayaka; Nakagawa, Kimie; Wada, Akimori; Takeda, Kazuyoshi; Takahashi, Kazuhiko; Tokiwa, Hiroaki; Okano, Toshio.

:: Journal of Medicinal Chemistry, 巻 54, 番号 13, 14.07.2011, p. 4918-4922.

研究成果: Article

Suhara, Yoshitomo ; Watanabe, Masato ; Motoyoshi, Sayaka ; Nakagawa, Kimie ; Wada, Akimori ; Takeda, Kazuyoshi ; Takahashi, Kazuhiko ; Tokiwa, Hiroaki ; Okano, Toshio. / Synthesis of new vitamin K analogues as steroid and xenobiotic receptor (SXR) agonists : Insights into the biological role of the side chain part of vitamin K. :: Journal of Medicinal Chemistry. 2011 ; 巻 54, 番号 13. pp. 4918-4922.
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AU - Nakagawa, Kimie

AU - Wada, Akimori

AU - Takeda, Kazuyoshi

AU - Takahashi, Kazuhiko

AU - Tokiwa, Hiroaki

AU - Okano, Toshio

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