Synthesis of new vitamin K analogues as steroid and xenobiotic receptor (SXR) agonists: Insights into the biological role of the side chain part of vitamin K

Yoshitomo Suhara; Masato Watanabe; Sayaka Motoyoshi; Kimie Nakagawa; Akimori Wada; Kazuyoshi Takeda; Kazuhiko Takahashi; Hiroaki Tokiwa; Toshio Okano

doi:10.1021/jm200201k

Synthesis of new vitamin K analogues as steroid and xenobiotic receptor (SXR) agonists: Insights into the biological role of the side chain part of vitamin K

Yoshitomo Suhara, Masato Watanabe, Sayaka Motoyoshi, Kimie Nakagawa, Akimori Wada, Kazuyoshi Takeda, Kazuhiko Takahashi, Hiroaki Tokiwa, Toshio Okano

研究成果: Article › 査読

21 被引用数 (Scopus)

抄録

Vitamin K₂ has been demonstrated to induce gene expression related to bone formation through a nuclear steroid and xenobiotic receptor (SXR). We synthesized new vitamin K analogues with the same isoprene side chains symmetrically introduced at the 2 and 3 positions of 1,4-naphthoquinone and evaluated the transcriptional activity of the target gene. The transcriptional activity was related to the length of the side chain which allowed optimal interaction with ligand-binding domain of SXR.

本文言語	English
ページ（範囲）	4918-4922
ページ数	5
ジャーナル	Journal of Medicinal Chemistry
巻	54
号	13
DOI	https://doi.org/10.1021/jm200201k
出版ステータス	Published - 2011 7月 14
外部発表	はい

ASJC Scopus subject areas

分子医療
創薬

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10.1021/jm200201k

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引用スタイル

Suhara, Y, Watanabe, M, Motoyoshi, S, Nakagawa, K, Wada, A, Takeda, K, Takahashi, K, Tokiwa, H & Okano, T 2011, 'Synthesis of new vitamin K analogues as steroid and xenobiotic receptor (SXR) agonists: Insights into the biological role of the side chain part of vitamin K', Journal of Medicinal Chemistry, vol. 54, no. 13, pp. 4918-4922. https://doi.org/10.1021/jm200201k

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AU - Takahashi, Kazuhiko

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