Synthesis of novel 1α,25-dihydroxy-19-norvitamin D3 with an amide conjugate

Yoshitomo Suhara, Keiichiro Ono, Akihiro Yoshida, Toshie Fujishima, Nozomi Saito, Shinobu Honzawa, Seishi Kishimoto, Takayuki Sugiura, Keizo Waku, Hiroaki Takayama, Atsushi Kittaka

研究成果: Article

4 引用 （Scopus）

抜粋

The diene system of 1α,25-dihydroxy-19-norvitamin D3 was replaced by a stable amide bond. A 3-hydroxypropoxy group, which was effective on enhancing binding affinity of 1α,25-dihydroxyvitamin D3 for vitamin D receptor (VDR), was introduced to the C2-position of the amide type analogue of 1α,25-dihydroxy-19-norvitamin D3. The amide analogue was found to be not suitable for binding to the ligand binding domain of the bovine thymus VDR, and additional modification at the C2-position did not improve the affinity. Potency in induction of HL-60 cell differentiation was evaluated for the novel amide analogues (3a-c).

元の言語English
ページ（範囲）423-436
ページ数14
ジャーナルHeterocycles
巻62
DOI
出版物ステータスPublished - 2004 1 1
外部発表Yes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

文献にアクセス

フィンガープリント Synthesis of novel 1α,25-dihydroxy-19-norvitamin D<sub>3</sub> with an amide conjugate' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

    • これを引用

    Suhara, Y., Ono, K., Yoshida, A., Fujishima, T., Saito, N., Honzawa, S., Kishimoto, S., Sugiura, T., Waku, K., Takayama, H., & Kittaka, A. (2004). Synthesis of novel 1α,25-dihydroxy-19-norvitamin D3 with an amide conjugate. Heterocycles, 62, 423-436. https://doi.org/10.3987/com-03-s(p)34