Synthesis of Novel Synthetic Vitamin K Analogues Prepared by Introduction of a Heteroatom and a Phenyl Group That Induce Highly Selective Neuronal Differentiation of Neuronal Progenitor Cells

Kimito Kimura, Yoshihisa Hirota, Shigefumi Kuwahara, Atsuko Takeuchi, Chisato Tode, Akimori Wada, Naomi Osakabe, Yoshitomo Suhara

研究成果: Article

6 引用 (Scopus)

抄録

We synthesized novel vitamin K2 analogues that incorporated a heteroatom and an aromatic ring in the side chain and evaluated their effect on the selective differentiation of neuronal progenitor cells into neurons in vitro. The results showed that a menaquinone-2 analogue bearing a p-fluoroaniline had the most potent activity, which was more than twice as great as the control. In addition, the neuronal selectivity was more than 3 times greater than the control.

元の言語English
ページ(範囲)2591-2596
ページ数6
ジャーナルJournal of Medicinal Chemistry
60
発行部数6
DOI
出版物ステータスPublished - 2017 3 23

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

これを引用

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abstract = "We synthesized novel vitamin K2 analogues that incorporated a heteroatom and an aromatic ring in the side chain and evaluated their effect on the selective differentiation of neuronal progenitor cells into neurons in vitro. The results showed that a menaquinone-2 analogue bearing a p-fluoroaniline had the most potent activity, which was more than twice as great as the control. In addition, the neuronal selectivity was more than 3 times greater than the control.",
author = "Kimito Kimura and Yoshihisa Hirota and Shigefumi Kuwahara and Atsuko Takeuchi and Chisato Tode and Akimori Wada and Naomi Osakabe and Yoshitomo Suhara",
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T1 - Synthesis of Novel Synthetic Vitamin K Analogues Prepared by Introduction of a Heteroatom and a Phenyl Group That Induce Highly Selective Neuronal Differentiation of Neuronal Progenitor Cells

AU - Kimura, Kimito

AU - Hirota, Yoshihisa

AU - Kuwahara, Shigefumi

AU - Takeuchi, Atsuko

AU - Tode, Chisato

AU - Wada, Akimori

AU - Osakabe, Naomi

AU - Suhara, Yoshitomo

PY - 2017/3/23

Y1 - 2017/3/23

N2 - We synthesized novel vitamin K2 analogues that incorporated a heteroatom and an aromatic ring in the side chain and evaluated their effect on the selective differentiation of neuronal progenitor cells into neurons in vitro. The results showed that a menaquinone-2 analogue bearing a p-fluoroaniline had the most potent activity, which was more than twice as great as the control. In addition, the neuronal selectivity was more than 3 times greater than the control.

AB - We synthesized novel vitamin K2 analogues that incorporated a heteroatom and an aromatic ring in the side chain and evaluated their effect on the selective differentiation of neuronal progenitor cells into neurons in vitro. The results showed that a menaquinone-2 analogue bearing a p-fluoroaniline had the most potent activity, which was more than twice as great as the control. In addition, the neuronal selectivity was more than 3 times greater than the control.

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U2 - 10.1021/acs.jmedchem.6b01717

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JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

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