Synthesis of Novel Synthetic Vitamin K Analogues Prepared by Introduction of a Heteroatom and a Phenyl Group That Induce Highly Selective Neuronal Differentiation of Neuronal Progenitor Cells

Kimito Kimura, Yoshihisa Hirota, Shigefumi Kuwahara, Atsuko Takeuchi, Chisato Tode, Akimori Wada, Naomi Osakabe, Yoshitomo Suhara

研究成果: Article査読

10 被引用数 (Scopus)

抄録

We synthesized novel vitamin K2 analogues that incorporated a heteroatom and an aromatic ring in the side chain and evaluated their effect on the selective differentiation of neuronal progenitor cells into neurons in vitro. The results showed that a menaquinone-2 analogue bearing a p-fluoroaniline had the most potent activity, which was more than twice as great as the control. In addition, the neuronal selectivity was more than 3 times greater than the control.

本文言語English
ページ(範囲)2591-2596
ページ数6
ジャーナルJournal of Medicinal Chemistry
60
6
DOI
出版ステータスPublished - 2017 3 23

ASJC Scopus subject areas

  • 分子医療
  • 創薬

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