抄録
Vitamin K is an essential cofactor of γ-glutamylcarboxylase as related to blood coagulation and bone formation. Menaquinone-4, one of the vitamin K homologues, is biosynthesized in the body and has various biological activities such as being a ligand for steroid and xenobiotic receptors, protection of neuronal cells from oxidative stress, and so on. From this background, we focused on the role of menaquinone in the differentiation activity of progenitor cells into neuronal cells and we synthesized novel vitamin K derivatives with modification of the ω-terminal side chain. We report here new vitamin K analogues, which introduced an alkylated phenyl group at the ω-terminal side chain. These compounds exhibited potent differentiation activity as compared to control.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 4881-4884 |
| ページ数 | 4 |
| ジャーナル | Bioorganic and Medicinal Chemistry Letters |
| 巻 | 27 |
| 発行部数 | 21 |
| DOI | |
| 出版物ステータス | Published - 2017 11 1 |
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ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry
これを引用
Synthesis of novel vitamin K derivatives with alkylated phenyl groups introduced at the ω-terminal side chain and evaluation of their neural differentiation activities. / Sakane, Rie; Kimura, Kimito; Hirota, Yoshihisa; Ishizawa, Michiyasu; Takagi, Yuta; Wada, Akimori; Kuwahara, Shigefumi; Makishima, Makoto; Suhara, Yoshitomo.
：: Bioorganic and Medicinal Chemistry Letters, 巻 27, 番号 21, 01.11.2017, p. 4881-4884.研究成果: Article
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TY - JOUR
T1 - Synthesis of novel vitamin K derivatives with alkylated phenyl groups introduced at the ω-terminal side chain and evaluation of their neural differentiation activities
AU - Sakane, Rie
AU - Kimura, Kimito
AU - Hirota, Yoshihisa
AU - Ishizawa, Michiyasu
AU - Takagi, Yuta
AU - Wada, Akimori
AU - Kuwahara, Shigefumi
AU - Makishima, Makoto
AU - Suhara, Yoshitomo
PY - 2017/11/1
Y1 - 2017/11/1
N2 - Vitamin K is an essential cofactor of γ-glutamylcarboxylase as related to blood coagulation and bone formation. Menaquinone-4, one of the vitamin K homologues, is biosynthesized in the body and has various biological activities such as being a ligand for steroid and xenobiotic receptors, protection of neuronal cells from oxidative stress, and so on. From this background, we focused on the role of menaquinone in the differentiation activity of progenitor cells into neuronal cells and we synthesized novel vitamin K derivatives with modification of the ω-terminal side chain. We report here new vitamin K analogues, which introduced an alkylated phenyl group at the ω-terminal side chain. These compounds exhibited potent differentiation activity as compared to control.
AB - Vitamin K is an essential cofactor of γ-glutamylcarboxylase as related to blood coagulation and bone formation. Menaquinone-4, one of the vitamin K homologues, is biosynthesized in the body and has various biological activities such as being a ligand for steroid and xenobiotic receptors, protection of neuronal cells from oxidative stress, and so on. From this background, we focused on the role of menaquinone in the differentiation activity of progenitor cells into neuronal cells and we synthesized novel vitamin K derivatives with modification of the ω-terminal side chain. We report here new vitamin K analogues, which introduced an alkylated phenyl group at the ω-terminal side chain. These compounds exhibited potent differentiation activity as compared to control.
KW - Menaquinone-4
KW - Neuronal cells
KW - SXR
KW - Transcriptional activity
KW - Vitamin K
UR - http://www.scopus.com/inward/record.url?scp=85029702205&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85029702205&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2017.09.038
DO - 10.1016/j.bmcl.2017.09.038
M3 - Article
C2 - 28947152
AN - SCOPUS:85029702205
VL - 27
SP - 4881
EP - 4884
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 21
ER -