@article{3dde3847bda94d65b46b297684b1c78d,
title = "Synthesis of novel vitamin K derivatives with alkylated phenyl groups introduced at the ω-terminal side chain and evaluation of their neural differentiation activities",
abstract = "Vitamin K is an essential cofactor of γ-glutamylcarboxylase as related to blood coagulation and bone formation. Menaquinone-4, one of the vitamin K homologues, is biosynthesized in the body and has various biological activities such as being a ligand for steroid and xenobiotic receptors, protection of neuronal cells from oxidative stress, and so on. From this background, we focused on the role of menaquinone in the differentiation activity of progenitor cells into neuronal cells and we synthesized novel vitamin K derivatives with modification of the ω-terminal side chain. We report here new vitamin K analogues, which introduced an alkylated phenyl group at the ω-terminal side chain. These compounds exhibited potent differentiation activity as compared to control.",
keywords = "Menaquinone-4, Neuronal cells, SXR, Transcriptional activity, Vitamin K",
author = "Rie Sakane and Kimito Kimura and Yoshihisa Hirota and Michiyasu Ishizawa and Yuta Takagi and Akimori Wada and Shigefumi Kuwahara and Makoto Makishima and Yoshitomo Suhara",
note = "Funding Information: We are grateful to The Naito Foundation (Y.S.) and the Fuji Foundation for Protein Research (Y.H.), Japan Food Chemical Research Foundation (Y.H.). This study was financially supported in part by a Grant-in-aid for Scientific Research < KAKENHI > (C) (grant number 16K08325 to Y.S.) and a Grant-in-aid for Scientific Research Young Scientists (B) (grant number 16K18924 to Y.H.) from Japan Society for Promotion of Science . Publisher Copyright: {\textcopyright} 2017 The Author(s)",
year = "2017",
month = nov,
day = "1",
doi = "10.1016/j.bmcl.2017.09.038",
language = "English",
volume = "27",
pages = "4881--4884",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "21",
}