Synthesis of novel vitamin K derivatives with alkylated phenyl groups introduced at the ω-terminal side chain and evaluation of their neural differentiation activities

Rie Sakane, Kimito Kimura, Yoshihisa Hirota, Michiyasu Ishizawa, Yuta Takagi, Akimori Wada, Shigefumi Kuwahara, Makoto Makishima, Yoshitomo Suhara

研究成果: Article査読

4 被引用数 (Scopus)

抄録

Vitamin K is an essential cofactor of γ-glutamylcarboxylase as related to blood coagulation and bone formation. Menaquinone-4, one of the vitamin K homologues, is biosynthesized in the body and has various biological activities such as being a ligand for steroid and xenobiotic receptors, protection of neuronal cells from oxidative stress, and so on. From this background, we focused on the role of menaquinone in the differentiation activity of progenitor cells into neuronal cells and we synthesized novel vitamin K derivatives with modification of the ω-terminal side chain. We report here new vitamin K analogues, which introduced an alkylated phenyl group at the ω-terminal side chain. These compounds exhibited potent differentiation activity as compared to control.

本文言語English
ページ(範囲)4881-4884
ページ数4
ジャーナルBioorganic and Medicinal Chemistry Letters
27
21
DOI
出版ステータスPublished - 2017 11 1

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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