Synthesis of novel vitamin K2 analogues with modification at the Ω-terminal position and their biological evaluation as potent steroid and xenobiotic receptor (SXR) agonists

Yoshitomo Suhara, Masato Watanabe, Kimie Nakagawa, Akimori Wada, Yoichi Ito, Kazuyoshi Takeda, Kazuhiko Takahashi, Toshio Okano

研究成果: Article

7 引用 (Scopus)

抄録

Vitamin K2 is a ligand for a nuclear receptor, steroid and xenobiotic receptor (SXR), that induces the gene expressions of CYP3A4. We synthesized vitamin K2 analogues with hydroxyl or phenyl groups at the Ω-terminal of the side chain. The up-regulation of SXR-mediated transcription of the target gene by the analogues was dependent on the length of the side chain and the hydrophobicity of the Ω-terminal residues. Phenyl analogue menaquinone-3 was as active as the known SXR ligand rifampicin.

元の言語English
ページ(範囲)4269-4273
ページ数5
ジャーナルJournal of Medicinal Chemistry
54
発行部数12
DOI
出版物ステータスPublished - 2011 6 23
外部発表Yes

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

これを引用

Synthesis of novel vitamin K2 analogues with modification at the Ω-terminal position and their biological evaluation as potent steroid and xenobiotic receptor (SXR) agonists. / Suhara, Yoshitomo; Watanabe, Masato; Nakagawa, Kimie; Wada, Akimori; Ito, Yoichi; Takeda, Kazuyoshi; Takahashi, Kazuhiko; Okano, Toshio.

:: Journal of Medicinal Chemistry, 巻 54, 番号 12, 23.06.2011, p. 4269-4273.

研究成果: Article

Suhara, Yoshitomo ; Watanabe, Masato ; Nakagawa, Kimie ; Wada, Akimori ; Ito, Yoichi ; Takeda, Kazuyoshi ; Takahashi, Kazuhiko ; Okano, Toshio. / Synthesis of novel vitamin K2 analogues with modification at the Ω-terminal position and their biological evaluation as potent steroid and xenobiotic receptor (SXR) agonists. :: Journal of Medicinal Chemistry. 2011 ; 巻 54, 番号 12. pp. 4269-4273.
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AU - Wada, Akimori

AU - Ito, Yoichi

AU - Takeda, Kazuyoshi

AU - Takahashi, Kazuhiko

AU - Okano, Toshio

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