Synthesis of optically active atropisomeric anilide derivatives and their application to asymmetric reaction

Osamu Kitagawa, T. Taguchi

研究成果: Article

9 引用 (Scopus)

抜粋

N-Substituted anilide derivatives bearing a large substitutent such as a tert-Bu group at the ortho-position have atropisomerism due to the high rotation barrier of the N-Ar bond and resist racemization. We have succeeded in the synthesis of such atropisomeric N-Ar amides, imides and lactams with high optically purity and definite absolute configuration, and the development of various asymmetric reactions using them. Furthermore, catalytic asymmetric reaction with such atropisomeric anilide as a chiral ligand is also described.

元の言語English
ページ(範囲)680-688
ページ数9
ジャーナルYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
59
発行部数7
出版物ステータスPublished - 2001
外部発表Yes

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ASJC Scopus subject areas

  • Organic Chemistry

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