抄録
N-Substituted anilide derivatives bearing a large substitutent such as a tert-Bu group at the ortho-position have atropisomerism due to the high rotation barrier of the N-Ar bond and resist racemization. We have succeeded in the synthesis of such atropisomeric N-Ar amides, imides and lactams with high optically purity and definite absolute configuration, and the development of various asymmetric reactions using them. Furthermore, catalytic asymmetric reaction with such atropisomeric anilide as a chiral ligand is also described.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 680-688 |
| ページ数 | 9 |
| ジャーナル | Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry |
| 巻 | 59 |
| 発行部数 | 7 |
| 出版物ステータス | Published - 2001 |
| 外部発表 | Yes |
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ASJC Scopus subject areas
- Organic Chemistry
これを引用
Synthesis of optically active atropisomeric anilide derivatives and their application to asymmetric reaction. / Kitagawa, Osamu; Taguchi, T.
：: Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, 巻 59, 番号 7, 2001, p. 680-688.研究成果: Article
}
TY - JOUR
T1 - Synthesis of optically active atropisomeric anilide derivatives and their application to asymmetric reaction
AU - Kitagawa, Osamu
AU - Taguchi, T.
PY - 2001
Y1 - 2001
N2 - N-Substituted anilide derivatives bearing a large substitutent such as a tert-Bu group at the ortho-position have atropisomerism due to the high rotation barrier of the N-Ar bond and resist racemization. We have succeeded in the synthesis of such atropisomeric N-Ar amides, imides and lactams with high optically purity and definite absolute configuration, and the development of various asymmetric reactions using them. Furthermore, catalytic asymmetric reaction with such atropisomeric anilide as a chiral ligand is also described.
AB - N-Substituted anilide derivatives bearing a large substitutent such as a tert-Bu group at the ortho-position have atropisomerism due to the high rotation barrier of the N-Ar bond and resist racemization. We have succeeded in the synthesis of such atropisomeric N-Ar amides, imides and lactams with high optically purity and definite absolute configuration, and the development of various asymmetric reactions using them. Furthermore, catalytic asymmetric reaction with such atropisomeric anilide as a chiral ligand is also described.
KW - Amide
KW - Anilide
KW - Asymmetric catalyst
KW - Asymmetric reaction
KW - Atropisomerism
KW - Chiral ligand
KW - Imide
KW - Lactam
KW - Optically active
UR - http://www.scopus.com/inward/record.url?scp=0034831891&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034831891&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0034831891
VL - 59
SP - 680
EP - 688
JO - Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
JF - Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
SN - 0037-9980
IS - 7
ER -