Synthetic Small Molecules Derived from Natural Vitamin K Homologues that Induce Selective Neuronal Differentiation of Neuronal Progenitor Cells

Yoshitomo Suhara, Yoshihisa Hirota, Norika Hanada, Shun Nishina, Sachiko Eguchi, Rie Sakane, Kimie Nakagawa, Akimori Wada, Kazuhiko Takahashi, Hiroaki Tokiwa, Toshio Okano

研究成果: Article

5 引用 (Scopus)

抜粋

We synthesized new vitamin K2 analogues with ω-terminal modifications of the side chain and evaluated their selective differentiation of neuronal progenitor cells into neurons in vitro. The result of the assay showed that the menaquinone-3 analogue modified with the m-methylphenyl group had the most potent activity, which was twice as great as the control. This finding indicated that it is possible to obtain much more potent compounds with modification of the structure of vitamin K2.

元の言語English
ページ(範囲)7088-7092
ページ数5
ジャーナルJournal of Medicinal Chemistry
58
発行部数17
DOI
出版物ステータスPublished - 2015 9 10

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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