Synthetic Small Molecules Derived from Natural Vitamin K Homologues that Induce Selective Neuronal Differentiation of Neuronal Progenitor Cells

Yoshitomo Suhara; Yoshihisa Hirota; Norika Hanada; Shun Nishina; Sachiko Eguchi; Rie Sakane; Kimie Nakagawa; Akimori Wada; Kazuhiko Takahashi; Hiroaki Tokiwa; Toshio Okano

doi:10.1021/acs.jmedchem.5b00999

Synthetic Small Molecules Derived from Natural Vitamin K Homologues that Induce Selective Neuronal Differentiation of Neuronal Progenitor Cells

Yoshitomo Suhara, Yoshihisa Hirota, Norika Hanada, Shun Nishina, Sachiko Eguchi, Rie Sakane, Kimie Nakagawa, Akimori Wada, Kazuhiko Takahashi, Hiroaki Tokiwa, Toshio Okano

研究成果: Article › 査読

8 被引用数 (Scopus)

抄録

We synthesized new vitamin K₂ analogues with ω-terminal modifications of the side chain and evaluated their selective differentiation of neuronal progenitor cells into neurons in vitro. The result of the assay showed that the menaquinone-3 analogue modified with the m-methylphenyl group had the most potent activity, which was twice as great as the control. This finding indicated that it is possible to obtain much more potent compounds with modification of the structure of vitamin K₂.

本文言語	English
ページ（範囲）	7088-7092
ページ数	5
ジャーナル	Journal of Medicinal Chemistry
巻	58
号	17
DOI	https://doi.org/10.1021/acs.jmedchem.5b00999
出版ステータス	Published - 2015 9月 10

ASJC Scopus subject areas

分子医療
創薬

文献へのアクセス

10.1021/acs.jmedchem.5b00999

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引用スタイル

Suhara, Y., Hirota, Y., Hanada, N., Nishina, S., Eguchi, S., Sakane, R., Nakagawa, K., Wada, A., Takahashi, K., Tokiwa, H., & Okano, T. (2015). Synthetic Small Molecules Derived from Natural Vitamin K Homologues that Induce Selective Neuronal Differentiation of Neuronal Progenitor Cells. Journal of Medicinal Chemistry, 58(17), 7088-7092. https://doi.org/10.1021/acs.jmedchem.5b00999

Suhara, Y , Hirota, Y, Hanada, N, Nishina, S, Eguchi, S, Sakane, R, Nakagawa, K, Wada, A, Takahashi, K, Tokiwa, H & Okano, T 2015, 'Synthetic Small Molecules Derived from Natural Vitamin K Homologues that Induce Selective Neuronal Differentiation of Neuronal Progenitor Cells', Journal of Medicinal Chemistry, vol. 58, no. 17, pp. 7088-7092. https://doi.org/10.1021/acs.jmedchem.5b00999

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abstract = "We synthesized new vitamin K2 analogues with ω-terminal modifications of the side chain and evaluated their selective differentiation of neuronal progenitor cells into neurons in vitro. The result of the assay showed that the menaquinone-3 analogue modified with the m-methylphenyl group had the most potent activity, which was twice as great as the control. This finding indicated that it is possible to obtain much more potent compounds with modification of the structure of vitamin K2.",

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AU - Nakagawa, Kimie

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