Synthetic Small Molecules Derived from Natural Vitamin K Homologues that Induce Selective Neuronal Differentiation of Neuronal Progenitor Cells

Yoshitomo Suhara, Yoshihisa Hirota, Norika Hanada, Shun Nishina, Sachiko Eguchi, Rie Sakane, Kimie Nakagawa, Akimori Wada, Kazuhiko Takahashi, Hiroaki Tokiwa, Toshio Okano

研究成果: Article

4 引用 (Scopus)

抄録

We synthesized new vitamin K<inf>2</inf> analogues with ω-terminal modifications of the side chain and evaluated their selective differentiation of neuronal progenitor cells into neurons in vitro. The result of the assay showed that the menaquinone-3 analogue modified with the m-methylphenyl group had the most potent activity, which was twice as great as the control. This finding indicated that it is possible to obtain much more potent compounds with modification of the structure of vitamin K<inf>2</inf>.

元の言語English
ページ(範囲)7088-7092
ページ数5
ジャーナルJournal of Medicinal Chemistry
58
発行部数17
DOI
出版物ステータスPublished - 2015 9 10

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

これを引用

Synthetic Small Molecules Derived from Natural Vitamin K Homologues that Induce Selective Neuronal Differentiation of Neuronal Progenitor Cells. / Suhara, Yoshitomo; Hirota, Yoshihisa; Hanada, Norika; Nishina, Shun; Eguchi, Sachiko; Sakane, Rie; Nakagawa, Kimie; Wada, Akimori; Takahashi, Kazuhiko; Tokiwa, Hiroaki; Okano, Toshio.

:: Journal of Medicinal Chemistry, 巻 58, 番号 17, 10.09.2015, p. 7088-7092.

研究成果: Article

Suhara, Yoshitomo ; Hirota, Yoshihisa ; Hanada, Norika ; Nishina, Shun ; Eguchi, Sachiko ; Sakane, Rie ; Nakagawa, Kimie ; Wada, Akimori ; Takahashi, Kazuhiko ; Tokiwa, Hiroaki ; Okano, Toshio. / Synthetic Small Molecules Derived from Natural Vitamin K Homologues that Induce Selective Neuronal Differentiation of Neuronal Progenitor Cells. :: Journal of Medicinal Chemistry. 2015 ; 巻 58, 番号 17. pp. 7088-7092.
@article{bbd5437256224c278607cd0b70ff1b8a,
title = "Synthetic Small Molecules Derived from Natural Vitamin K Homologues that Induce Selective Neuronal Differentiation of Neuronal Progenitor Cells",
abstract = "We synthesized new vitamin K2 analogues with ω-terminal modifications of the side chain and evaluated their selective differentiation of neuronal progenitor cells into neurons in vitro. The result of the assay showed that the menaquinone-3 analogue modified with the m-methylphenyl group had the most potent activity, which was twice as great as the control. This finding indicated that it is possible to obtain much more potent compounds with modification of the structure of vitamin K2.",
author = "Yoshitomo Suhara and Yoshihisa Hirota and Norika Hanada and Shun Nishina and Sachiko Eguchi and Rie Sakane and Kimie Nakagawa and Akimori Wada and Kazuhiko Takahashi and Hiroaki Tokiwa and Toshio Okano",
year = "2015",
month = "9",
day = "10",
doi = "10.1021/acs.jmedchem.5b00999",
language = "English",
volume = "58",
pages = "7088--7092",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
publisher = "American Chemical Society",
number = "17",

}

TY - JOUR

T1 - Synthetic Small Molecules Derived from Natural Vitamin K Homologues that Induce Selective Neuronal Differentiation of Neuronal Progenitor Cells

AU - Suhara, Yoshitomo

AU - Hirota, Yoshihisa

AU - Hanada, Norika

AU - Nishina, Shun

AU - Eguchi, Sachiko

AU - Sakane, Rie

AU - Nakagawa, Kimie

AU - Wada, Akimori

AU - Takahashi, Kazuhiko

AU - Tokiwa, Hiroaki

AU - Okano, Toshio

PY - 2015/9/10

Y1 - 2015/9/10

N2 - We synthesized new vitamin K2 analogues with ω-terminal modifications of the side chain and evaluated their selective differentiation of neuronal progenitor cells into neurons in vitro. The result of the assay showed that the menaquinone-3 analogue modified with the m-methylphenyl group had the most potent activity, which was twice as great as the control. This finding indicated that it is possible to obtain much more potent compounds with modification of the structure of vitamin K2.

AB - We synthesized new vitamin K2 analogues with ω-terminal modifications of the side chain and evaluated their selective differentiation of neuronal progenitor cells into neurons in vitro. The result of the assay showed that the menaquinone-3 analogue modified with the m-methylphenyl group had the most potent activity, which was twice as great as the control. This finding indicated that it is possible to obtain much more potent compounds with modification of the structure of vitamin K2.

UR - http://www.scopus.com/inward/record.url?scp=84941578422&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941578422&partnerID=8YFLogxK

U2 - 10.1021/acs.jmedchem.5b00999

DO - 10.1021/acs.jmedchem.5b00999

M3 - Article

C2 - 26305288

AN - SCOPUS:84941578422

VL - 58

SP - 7088

EP - 7092

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

SN - 0022-2623

IS - 17

ER -