The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression

Hiroaki Suzuki, Megumi Kurita, Kiyohisa Mizumoto, Masatsugu Moriyama, Sadakazu Aiso, Ikuo Nishimoto, Masaaki Matsuoka

研究成果: Article

11 引用 (Scopus)

抜粋

The ARF tumor suppressor gene antagonizes generation of various tumors. ARF-mediated tumor suppression occurs in a p53-independent manner as well as in a p53-dependent manner. We here demonstrate that BCL6 is a target of the ARF tumor suppressor. Either mouse p19 ARF or human p14 ARF binds to BCL6 and downregulates BCL6-induced transcriptional repression. ARF-mediated downregulation of the BCL6 activity may account in part for ARF-mediated tumor suppression.

元の言語English
ページ(範囲)242-248
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
326
発行部数1
DOI
出版物ステータスPublished - 2004 12 31
外部発表Yes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

フィンガープリント The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用