@article{f8cd612302844155a3ba022f86e3976d,
title = "Three-dimensional elemental mapping of hollow Fe 2O 3@SiO 2 mesoporous spheres using scanning confocal electron microscopy",
abstract = "Energy filtered scanning confocal electron microscopy (EFSCEM) in an aberration-corrected transmission electron microscope offers an approach for three-dimensional imaging and chemical analysis of nanoscale materials related to the well-established technique of confocal scanning optical microscopy. Here, we apply EFSCEM to the compositional analysis of the core structure in candidate structures for targeted drug delivery. Element-specific optical sectioning along the specimen depth direction demonstrates the presence of additional Si in a nominal Fe 2O 3 core. The presence of Si in the core is consistent with a specific formation mechanism for the hollow structure of the core.",
author = "Peng Wang and Ayako Hashimoto and Masaki Takeguchi and Kazutaka Mitsuishi and Masayuki Shimojo and Yufang Zhu and Mitsuhiro Okuda and Kirkland, {Angus I.} and Nellist, {Peter D.}",
note = "Funding Information: P.W., A.I.K., and P.D.N. acknowledge financial support from the Leverhulme Trust (F/08 749/B) and the EPSRC (EP/F048009/1). K.M. and A.H would like to acknowledge financial support from a Grant-in-Aid for Scientific Research (C) 2009-218577 and for Young Scientists (B) 20760027, respectively. Technical assistance from JEOL Ltd and JEOL (UK) Ltd is also gratefully acknowledged. Part of this work was supported by the Japan Society for the Promotion of Science, Japan-UK Research Cooperative Program. Copyright: Copyright 2012 Elsevier B.V., All rights reserved.",
year = "2012",
month = may,
day = "21",
doi = "10.1063/1.4714889",
language = "English",
volume = "100",
journal = "Applied Physics Letters",
issn = "0003-6951",
publisher = "American Institute of Physics Publising LLC",
number = "21",
}