Usefulness verification of handheld photoacoustic imaging system for evaluating hypodermal tissue

Yo Uchimoto, Takeshi Namita, Kengo Kondo, Makoto Yamakawa, Tsuyoshi Shiina

研究成果: Conference contribution

抄録

Knowing the elapsed time from subcutaneous hematoma generation can suggest appropriate treatment strategies. Today, ultrasound imaging, X-ray CT, and MRI are mainly used for diagnosis. However, they have difficulty in distinguishing hematoma from surrounding tissues because of their low image contrast and large device size. Furthermore, X-ray CT entails radio exposure; MRI is contraindicated for patients with embedded metal such as pacemakers. This study evaluated the feasibility of visualizing hematoma and evaluating its characterization using the handheld photoacoustic imaging system we developed. To evaluate the feasibility of estimating the bilirubin concentration, which increases as time passes from hematoma generation, simulated hematomas containing different bilirubin concentrations embedded into optical and acoustical transparent media were measured. Measurements of simulated hematoma using biological tissues were also conducted. The samples and linear ultrasound probe were set in degassed water. Pulses of laser light were guided to the sample surface by an optical fiber bundle close to the probe. Photoacoustic signals were obtained at 700-1030 nm wavelengths. Then photoacoustic spectra at high brightness areas in reconstructed images were calculated. Spectra differed by bilirubin concentrations. The photoacoustic signal ratio between two wavelengths was calculated. For both measurements, the feasibility of estimating bilirubin concentration using wavelengths of around 700 nm and around 900 nm were indicated. These analyses demonstrated the feasibility of visualizing subcutaneous hematoma and of evaluating its characterization using our handheld photoacoustic imaging system with multiple wavelengths.

本文言語English
ホスト出版物のタイトルPhotons Plus Ultrasound
ホスト出版物のサブタイトルImaging and Sensing 2019
編集者Lihong V. Wang, Alexander A. Oraevsky
出版社SPIE
ISBN(電子版)9781510623989
DOI
出版ステータスPublished - 2019
外部発表はい
イベントPhotons Plus Ultrasound: Imaging and Sensing 2019 - San Francisco, United States
継続期間: 2019 2月 32019 2月 6

出版物シリーズ

名前Progress in Biomedical Optics and Imaging - Proceedings of SPIE
10878
ISSN(印刷版)1605-7422

Conference

ConferencePhotons Plus Ultrasound: Imaging and Sensing 2019
国/地域United States
CitySan Francisco
Period19/2/319/2/6

ASJC Scopus subject areas

  • 電子材料、光学材料、および磁性材料
  • 原子分子物理学および光学
  • 生体材料
  • 放射線学、核医学およびイメージング

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