Vascular branching point counts using photoacoustic imaging in the superficial layer of the breast: A potential biomarker for breast cancer

Iku Yamaga, Nobuko Kawaguchi-Sakita, Yasufumi Asao, Yoshiaki Matsumoto, Aya Yoshikawa, Toshifumi Fukui, Masahiro Takada, Masako Kataoka, Masahiro Kawashima, Elham Fakhrejahani, Shotaro Kanao, Yoshie Nakayama, Mariko Tokiwa, Masae Torii, Takayuki Yagi, Takaki Sakurai, Hironori Haga, Kaori Togashi, Tsuyoshi Shiina, Masakazu Toi

研究成果: Article査読

19 被引用数 (Scopus)

抄録

This study aimed to identify the characteristics of the vascular network in the superficial subcutaneous layer of the breast and to analyze differences between breasts with cancer and contralateral unaffected breasts using vessel branching points (VBPs) detected by three-dimensional photoacoustic imaging with a hemispherical detector array. In 22 patients with unilateral breast cancer, the average VBP counts to a depth of 7 mm below the skin surface were significantly greater in breasts with cancer than in the contralateral unaffected breasts (p < 0.01). The ratio of the VBP count in the breasts with cancer to that in the contralateral breasts was significantly increased in patients with a high histologic grade (p = 0.03), those with estrogen receptor-negative disease (p < 0.01), and those with highly proliferative disease (p < 0.01). These preliminary findings indicate that a higher number of VBPs in the superficial subcutaneous layer of the breast might be a biomarker for primary breast cancer.

本文言語English
ページ(範囲)6-13
ページ数8
ジャーナルPhotoacoustics
11
DOI
出版ステータスPublished - 2018 9月
外部発表はい

ASJC Scopus subject areas

  • 原子分子物理学および光学
  • 放射線学、核医学およびイメージング

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